Unveiling the mechanism protecting replicated DNA from degradation

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Researchers have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein degradation system. Consequently, they were able to gain unprecedented access to the mechanism behind how AND-1 works during DNA replication and cell proliferation in vertebrate cells, demonstrating that AND-1 has two different functions during DNA replication mediated by different domains of AND-1.

New insights into the structure of a killer protein

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Researchers have gained new insights into the structure of the killer protein Bax. The protein induces programmed cell death, the method by which the body disposes of cells that are no longer needed or have been pathologically altered. Since Bax is constantly changing its location in the cell, its structure is difficult to investigate.